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Philip A Cole Selected Research

Therapeutics

2/2024p300 KAT regulates SOX10 stability and function in human melanoma.
2/2024The CoREST repressor complex mediates phenotype switching and therapy resistance in melanoma.
9/2011Inhibition of the acetyltransferases p300 and CBP reveals a targetable function for p300 in the survival and invasion pathways of prostate cancer cell lines.
12/2010BCL6 repression of EP300 in human diffuse large B cell lymphoma cells provides a basis for rational combinatorial therapy.
7/2009In vitro enzymatic characterization of near full length EGFR in activated and inhibited states.
11/2007Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface.
6/2004Bisubstrate analogue structure-activity relationships for p300 histone acetyltransferase inhibitors.
6/2002Serotonin N-acetyltransferase: mechanism and inhibition.

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Philip A Cole Research Topics

Disease

44Neoplasms (Cancer)
02/2024 - 10/2002
6Melanoma (Melanoma, Malignant)
02/2024 - 11/2002
4Prostatic Neoplasms (Prostate Cancer)
01/2019 - 09/2011
3Carcinoma (Carcinomatosis)
11/2021 - 09/2010
3Leukemia
12/2016 - 07/2005
3Hepatocellular Carcinoma (Hepatoma)
07/2012 - 09/2005
2Squamous Cell Carcinoma (Epidermoid Carcinoma)
01/2020 - 01/2019
2Carcinogenesis
01/2019 - 09/2010
2Pneumonia (Pneumonitis)
03/2014 - 10/2011
2Weight Gain
04/2013 - 12/2010
2Inflammation (Inflammations)
10/2011 - 05/2010
2Genetic Translocation (Chromosomal Translocation)
08/2011 - 09/2010
2Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
08/2011 - 09/2005
2Genomic Instability
02/2011 - 07/2008
2T-Cell Leukemia (Leukemia, T Cell)
05/2003 - 07/2002
1Pain (Aches)
12/2023
1Seasonal Affective Disorder
11/2023
1Disease Progression
11/2023
1Muscular Atrophy (Muscle Atrophy)
11/2023
1Muscular Diseases (Myopathy)
11/2023
1Nemaline Myopathies (Nemaline Myopathy)
11/2023
1Wounds and Injuries (Trauma)
08/2023
1Reperfusion Injury
01/2021
1Colorectal Neoplasms (Colorectal Cancer)
01/2020
1Neoplasm Metastasis (Metastasis)
01/2019
1Immune System Diseases (Immune Disorders)
05/2017
1Endotoxemia
01/2017
1Insulin Resistance
01/2017
1Hyperglycemia
01/2017
1Obesity
01/2017
1Metabolic Syndrome (Dysmetabolic Syndrome X)
10/2015
1Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
11/2011
1Fibrosis (Cirrhosis)
10/2011

Drug/Important Bio-Agent (IBA)

14Proteins (Proteins, Gene)FDA Link
02/2024 - 10/2002
12Histones (Histone)IBA
10/2022 - 07/2002
10Histone Acetyltransferases (Histone Acetyltransferase)IBA
01/2021 - 10/2002
8EnzymesIBA
11/2023 - 06/2004
5Transcription Factors (Transcription Factor)IBA
02/2024 - 10/2002
5Histone Deacetylases (Histone Deacetylase)IBA
08/2023 - 07/2005
5LipidsIBA
01/2022 - 01/2016
4ChromatinIBA
08/2023 - 07/2002
4Protein Kinases (Protein Kinase)IBA
01/2022 - 01/2018
4Histone Deacetylase InhibitorsIBA
11/2021 - 06/2014
4Phosphoric Monoester Hydrolases (Phosphatases)IBA
10/2021 - 01/2016
4Phosphotransferases (Kinase)IBA
01/2020 - 11/2011
4Lysine (L-Lysine)FDA Link
01/2020 - 10/2002
3UbiquitinIBA
11/2023 - 05/2017
3Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA
11/2023 - 01/2018
3AcetyltransferasesIBA
10/2021 - 09/2011
3GhrelinIBA
10/2015 - 12/2010
3ErbB Receptors (EGF Receptor)IBA
11/2011 - 06/2006
2Proteasome Endopeptidase Complex (Proteasome)IBA
02/2024 - 11/2023
2Co-Repressor ProteinsIBA
02/2024 - 07/2005
2Protein Isoforms (Isoforms)IBA
12/2023 - 01/2021
2PTEN Phosphohydrolase (PTEN Phosphatase)IBA
01/2022 - 01/2021
2Phospholipids (Phosphatides)FDA LinkGeneric
10/2021 - 01/2020
2p300-CBP-associated factorIBA
01/2019 - 01/2017
2I-CBP112IBA
01/2019 - 12/2016
2AndrogensIBA
10/2017 - 09/2011
2Androgen Receptors (Androgen Receptor)IBA
10/2017 - 09/2011
2LipopolysaccharidesIBA
01/2017 - 05/2010
2Peptide Hormones (Polypeptide Hormones)IBA
10/2015 - 12/2010
2DNA (Deoxyribonucleic Acid)IBA
10/2013 - 07/2005
2GO-CoA-TatIBA
04/2013 - 12/2010
2Peptides (Polypeptides)IBA
10/2011 - 03/2004
2Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
06/2006 - 05/2006
2Trans-Activators (Trans-Acting Factor)IBA
03/2004 - 05/2003
1Lysine AcetyltransferasesIBA
02/2024
1p38 Mitogen-Activated Protein KinasesIBA
02/2024
1ElementsIBA
02/2024
1Voltage-Gated Sodium ChannelsIBA
12/2023
1Arylalkylamine N-AcetyltransferaseIBA
11/2023
1MelatoninIBA
11/2023
1ProteomeIBA
11/2023
1PanobinostatIBA
11/2021
1TensinsIBA
10/2021
1Oncogene Proteins (Oncogene Protein)IBA
01/2020
1NEO2734IBA
01/2020
1entinostat (MS 275)IBA
01/2019
1Microphthalmia-Associated Transcription FactorIBA
01/2019
1CREB-Binding ProteinIBA
10/2017
1Ligases (Synthetase)IBA
05/2017
1Insulin (Novolin)FDA Link
01/2017
1LigandsIBA
12/2016
1phosphatidylinositol 3,4,5-triphosphateIBA
07/2016
1Phosphatidylinositols (Phosphatidylinositol)IBA
01/2016
1Membrane Proteins (Integral Membrane Proteins)IBA
10/2015
1AcyltransferasesIBA
10/2015
1MethyltransferasesIBA
12/2014
1Histone DemethylasesIBA
09/2014
1Fc Receptors (Fc Receptor)IBA
03/2014
1Cisplatin (Platino)FDA LinkGeneric
10/2013
1T-Cell Antigen Receptors (T-Cell Receptor)IBA
09/2013
1MicroRNAs (MicroRNA)IBA
07/2012
1Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA
11/2011
1Hyaluronic Acid (Hyaluronan)IBA
10/2011

Therapy/Procedure

8Therapeutics
02/2024 - 06/2002
2Castration
10/2017 - 09/2011
1Drug Therapy (Chemotherapy)
01/2020
1Immunotherapy
09/2013